2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
    Neuronal Signaling
  4. Calcium Channel

Calcium Channel

Ca2+ channels; Ca channels

Calcium Channel

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Calcium channel is an ion channel which displays selective permeability to calcium ions. It is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels. Voltage-gated calcium (CaV) channels catalyse rapid, highly selective influx of Ca2+ into cells despite a 70-fold higher extracellular concentration of Na+. Some calcium channel blockers have the added benefit of slowing your heart rate, which can further reduce blood pressure, relieve chest pain (angina) and control an irregular heartbeat.

Calcium Channel Isoform Specific Products:

Calcium Channel Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-U00049B
    Mioflazine dihydrochloride
    		Antagonist
    Mioflazine dihydrochloride is a nucleoside transport inhibitor with sleep-improving activity. Mioflazine dihydrochloride significantly improves cardiac survival after global cardiac ischemia. Mioflazine dihydrochloride reduces the mitochondrial calcium content in guinea-pig. Mioflazine dihydrochloride does not exhibit inotropic effects during induction and nursing.
    Mioflazine dihydrochloride
  • HY-106810
    Naltiazem
    		Antagonist
    Naltiazem (Ro 23-6152) is a thiazepinone-type calcium antagonist. Naltiazem inhibits platelet aggregation in vitro and in vivo.
    Naltiazem
  • HY-16213
    FURNIDIPINE
    		Antagonist
    FURNIDIPINE, an orally active cardio-protective agent, possesses anti-arrhythmic and antihypertensive effects.
    FURNIDIPINE
  • HY-119492
    Phenchlobenpyrrone
    		Antagonist
    Phenchlobenpyrrone is a highly selective neuronal calcium antagonist that crosses the blood-brain barrier. Phenchlobenpyrrone mildly inhibits AChE activity. Phenchlobenpyrrone inhibits Aβ aggregation and promotes the clearance of Aβ oligomers. Phenchlobenpyrrone reduces abnormal phosphorylation of Tau protein. Phenchlobenpyrrone may be used in research on Alzheimer's disease.
    Phenchlobenpyrrone
  • HY-101685A
    Iganidipine dihydrochloride
    		Antagonist
    Iganidipine dihydrochloride is a Ca2+ antagonist.
    Iganidipine dihydrochloride
  • HY-14284S
    Nilvadipine-d4
    		Antagonist
    Nilvadipine-d4 is deuterium labeled Nilvadipine. Nilvadipine is a potent calcium channel antagonist, and the IC50 value is around 0.1 nM.
    Nilvadipine-d<sub>4</sub>
  • HY-116400
    BN 50341
    		Antagonist
    BN 50341 is an orally active anticalcic agent and a benzazepine derivative. BN 50341 decreases the in vivo electrically induced thrombus formation in rat or guinea-pig artery and can be utilized in cardiovascular research.
    BN 50341
  • HY-108974S
    Drotaverine-d10 hydrochloride
    		Antagonist
    Drotaverine-d10 (hydrochloride) is the deuterium labeled Drotaverine hydrochloride. Drotaverine hydrochloride is a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor and an L-type voltage-dependent calcium channel (L-VDCC) blocker, blocks the degradation of 3',5'-cyclic adenosine monophosphate. Drotaverine hydrochloride exhibits in vivo antispasmodic efficacy without anticholinergic effects.
    Drotaverine-d<sub>10</sub> hydrochloride
  • HY-165572
    AJ-3941
    		Antagonist
    AJ-3941 is an orally active cerebrovascular-selective Calcium Channel antagonist having anti-lipid peroxidative action. AJ-3941 can ameliorate the brain infarction and edema after permanent focal cerebral ischemia.
    AJ-3941
  • HY-W184837
    m-Nisoldipine
    		Antagonist
    m-Nisoldipine (KR-1008) is a dihydropyridine calcium antagonist that can significantly increase cardiac output and heart index, significantly reduce the negative inotropic effect on the myocardium, and has a relatively high selectivity for the thoracic aorta. m-Nisoldipine can be used in the research of cardiovascular diseases.
    m-Nisoldipine
  • HY-118030
    RQ-00311651
    		Antagonist
    RQ-00311651 is a T-type calcium channel blocker that specifically targets the Cav3.2 isoform with a role in neuropathic and visceral pain. RQ-00311651 significantly inhibits T currents in HEK293 cells expressing human Cav3.1 or Cav3.2. RQ-00311651 also inhibited high potassium-induced calcium signaling. RQ-00311651 also inhibits antiallergic properties in rats and mice with neuropathic pain induced by spinal nerve injury or Paclitaxel (HY-B0015). Oral and intraperitoneal injection (10-20 mg/kg) inhibits Cerulein (HY-A0190)-induced acute pancreatitis and cyclophosphamide-induced cystitis in mice.
    RQ-00311651
  • HY-131942
    sFTX-3.3
    		Antagonist
    sFTX-3.3 is a Ca2+ channel antagonist with IC50s of approximately 0.24 mM and 0.70 mM against P-type and N-type channels.
    sFTX-3.3
  • HY-N0215S9
    L-Phenylalanine-13C9,15N,d8
    		Antagonist
    L-Phenylalanine-13C9,15N,d8 is the deuterium, 13C-, and 15-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals.
    L-Phenylalanine-<sup>13</sup>C<sub>9</sub>,<sup>15</sup>N,d<sub>8</sub>
  • HY-B0317H
    Amlodipine orotate
    		Antagonist
    Amlodipine orotate, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine orotate can be used for the research of high blood pressure and cancer.
    Amlodipine orotate
  • HY-135328AS
    Norverapamil-d7 hydrochloride
    		Antagonist 98.86%
    Norverapamil-d7 (hydrochloride) is a deuterium labeled Norverapamil. Norverapamil ((±)-Norverapamil), an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor.
    Norverapamil-d<sub>7</sub> hydrochloride
  • HY-108997A
    Palonidipine hydrochloride
    		Antagonist
    Palonidipine hydrochloride is a calcium antagonist which is potential for the therapy of angina-pectoris and hypertension.
    Palonidipine hydrochloride
  • HY-B0284S1
    Nifedipine-d4
    		Antagonist
    Nifedipine-d4 is the deuterium labeled Nifedipine. Nifedipine (BAY-a-1040) is a potent calcium channel blocker and agent of choice for cardiac insufficiencies.
    Nifedipine-d<sub>4</sub>
  • HY-105365
    PD 175069
    		Antagonist
    PD 175069 is a potent and selective N-type calcium channel antagonist with an IC50 of 0.32 μM. PD 175069 is efficacious in an audiogenic seizure model using DBA/2 mice. PD 175069 can be used for research on neurological conditions such as neuropathic pain and stroke.
    PD 175069
  • HY-106810A
    Naltiazem hydrochloride
    		Antagonist
    Naltiazem (Ro 23-6152) hydrochloride is a thiazepinone-type calcium antagonist. Naltiazem hydrochloride inhibits platelet aggregation in vitro and in vivo.
    Naltiazem hydrochloride
  • HY-P10898
    GeX-2
    		Antagonist
    GeX-2 is a truncated analogue of αO-conotoxin. GeX-2 activates GABAB receptor. GeX-2 inhibits α9α10 nAChR and CaV2.2 channels. GeX-2 alleviates pain in the rat model of chronic constriction injury.
    GeX-2
Cat. No. Product Name / Synonyms Application Reactivity
Calcium Channel Isoform Comparison

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